If you think about it, that’s equivalent to the number of people living in a relatively large city. And according to the Lupus Foundation of America, more than 1,600 new cases are diagnosed in America alone each year. Worldwide, 5 million people are thought to be affected by this disease.

So who gets lupus?

Lupus is a disease that mainly affects women between the ages of 15 and 44, according to the Lupus Foundation of America. That said, males, as in Seal’s case, can develop lupus too. However, the demographic most affected falls in the aforementioned age range.

And though the disease can strike those of any race, some are at higher risk than others. “Women of color are two to three times more likely to develop lupus than Caucasians,” according to the Lupus Foundation of America.

Celebrities, especially those affected by lupus, have been strong advocates of awareness of this disease, which has helped to take it out of the shadows and into the limelight.

Bet you’re wondering just who these celebrities are. Following are six celebrities who have lupus (or have tested borderline positive for lupus).

1.    Nick Cannon

America’s Got Talent host Nick Cannon learned that he had lupus in 2012. Cannon is affected by a form of lupus called lupus nephritis. This disease is known to affect the kidneys. Since then, he’s made an effort to raise awareness about the disease.